Scientists develop 3D printed human skin for the treatment of burns
Recently, researchers at Charles III University in Madrid have demonstrated for the first time that human skin can be created using new 3D printing technology.
It is reported that this newly developed method of improving the printer with healthy skin cells covering the wound can make traditional burn treatment a history.
According to Jose Luis Jorcano, one of the authors, the skin can be transplanted to patients or used in a commercial environment to quantify test chemicals, cosmetics or pharmaceuticals.
This new human skin is one of the first living human organs introduced into the market using bio-printing technology. It replicates the natural structure of the skin, with a first outer layer, a skin and its stratum corneum, and another thicker, deeper layer of dermis. The last layer consists of fibroblasts that produce collagen, a protein that imparts elasticity and mechanical strength to the skin.
According to experts, Bioink is the key to bio 3D printing. When creating skin, use a syringe with a biological component instead of a cartridge and color ink.
In the words of researcher Juan Francisco del Canizo, “understand how to mix biological components, under what conditions work with them, so that cells do not deteriorate, and how to properly deposit the product is critical to the system. Licensed by the BioDan Group CIEMAT patent The act of storing these biological sources is controlled by a computer that stores them in an orderly manner on the print bed to create skin."
The methods used to produce these tissues can be carried out in two ways: from the large-scale cell bank for industrial processes to produce allogeneic skin; the other is to create autologous skin from the patient's cells depending on the patient's particular circumstances. This is mainly used for therapeutic purposes, such as the treatment of severe burns. We use only human cells and components to produce bioactive skin and can produce our own human collagen, avoiding the use of animal collagen found in other methods. "They point out that this is not the end of the story, because they are also studying ways to print other human tissues."
"This new technology has several advantages: the bioprinting method allows the skin to be produced in a standardized, automated manner, and the process is cheaper than manual production," said Alfredo Brisac, CEO of BioDan Group. He is a Spanish bioengineering company specializing in regenerative medicine and is working with it to research and commercialize this technology.
Currently, the technology is in the process of approval by European regulators to ensure that the skin produced is sufficient for skin grafts for burn patients and other skin problems. In addition, these organizations can be used to test pharmaceutical products, as well as cosmetic and consumer chemical products, and current regulations require testing without animals.
It is reported that the research results were published in the journal "Biological Products".
(Editor)
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