Structure of quaternary cytokine receptor complex
(Cover image: the asymmetric structure of the gp130 / LIF-R / CNTF-Rα / CNTF quaternary complex, the figure shows the leukemia inhibitory factor receptor LIF-R (purple), gp130 (blue), ciliary nerve The nutrient factor CNTF (yellow) and the CNTF receptor CNTF-R (green).)
Leukemia Inhibitory Factor Receptor LIF-R and gp130 are signal receptors that are widely shared by various cytokines. These cytokines are closely related to cell growth, cell differentiation and other processes, including the ciliary nerve Nutrition factor (Ciliary Neurotrophic Factor CNTF) and its receptor.
Glycoprotein gp130 is a receptor shared by at least 9 cytokines, and gp130 can act as a signaling homodimer or heterodimer for leukemia inhibitory factor receptors. In the "Molecular Cell" published on September 5, 2008, a group of scientists from the United States published their latest research results in the form of a cover article. In the article, the researchers said that they The full-length, transmembrane structure of a quaternary cytokine receptor complex is determined structurally. This cytokine receptor complex contains gp130, LIF-R, the cytokine ciliary neurotrophic factor and its alpha receptor (CNTF-Rα).
Thermodynamic analysis results show that, unlike the symmetrical gp130 / interleukin-6 / IL-6Rα hexamer complex formed by cooperation, CNTF / CNTF-Rα combines with gp130 and LIF-R in a non-cooperative form, and Finally, an asymmetric 1: 1: 1: 1 ratio complex is formed. Single-particle electron microscopy analysis of the full-length gp130 / LIF-R / CNTF-Rα / CNTF quaternary complex confirmed this asymmetric structure, in which the extracellular and transmembrane receptor parts are combined into a continuous structure . The asymmetric extracellular structure of this cell surface signaling complex is formed by a set of organizational rules, and this rule applies to the entire family of cytokine receptors.
For the full-length quaternary complex, its structure contains transmembrane and intracellular parts, and the LIF-R and gp130 receptors combine in the near-membrane region to form receptors that enter the cell membrane, and related structural analysis shows that the receptor The connection between the extracellular and transmembrane parts is very strong. This strength allows structural vibrations outside the cell to be more easily transmitted to the cell through the cell membrane. In addition, the article also cited other gp130 family cytokine receptor organization rules, including LIF, IL-27, IL-12 and so on.
These home decorations are the prevalent trends in modern interior design, can create a modern artistic atmosphere, make your room modern and style look, also its colors give a refreshing feel, adding color and life to the whole room.
Home Decoration,Home Decoration,Bathroom Mat,Anti Fatigue Bathroom Rug,Rubber Bath Mats,Toilet Pedestal Mat
HISMOK(SHENZHEN)TECHNOLOGY CO.,LTD , https://www.will-trade.com