The most complete "metaphy" map of the human body to date
Researchers at the University of California, San Diego and an international association university have created the most comprehensive virtual reconstruction of human metabolism model, "Recon 2", like Google Maps on the basis of early pioneering work. "Scout 2" can identify the cause of the disease and propose new targeted treatments for cancer, diabetes, and even mental and neurodegenerative diseases. The research results are published online in the latest issue of "Nature Biotechnology" (Nature Biotechnology).
Metabolism can convert food into energy and molecules needed by the body, and metabolic imbalance is a potential pathogenic factor. Scientists have built a broad and interactive database of metabolic information based on the human genome and systems biology with the help of high-efficiency computers. Bernhard Paulson, a professor of bioengineering at the Jacobs School of Engineering at the University of California, San Diego, said that based on the continuous improvement of the original "Scout 1", the "Scout 2" has been developed to enable biomedical personnel to study human metabolism Is more accurate than ever in order to understand how certain metabolic pathways deviate and cause disease.
"Recon 2" is likened to Google Maps because of its ability to merge complex details into a single, interactive map. For example, when the researchers observe how the growth and metabolism of cancer tumors progress, they can zoom in on the detailed images of individual metabolic reactions on the map or zoom out to see the relationship with other metabolisms. It ’s like Google Maps that gathers a lot of data and merges pictures, addresses, streets, and traffic into a comprehensive tool for navigation. The model compiles a large number of published literatures and existing metabolic process models.
"Scout 2" can show researchers the human metabolic network from multiple angles and provide necessary background data. One of the most promising applications of the human metabolic network is targeted drug delivery that can determine specific gene expression and its metabolic pathways. With "Scout 2", researchers can use the existing gene database and the entire metabolic network map to find specific metabolic pathways that affect the growth of cancer cells, and then through virtual experiments to verify which drugs can repair metabolic imbalance diseases.
"Scout 2" will undoubtedly accelerate the development of personalized diagnosis and treatment. In the future, doctors can develop virtual models of personal metabolic networks for patients and determine the most effective treatment options for various diseases, including diabetes, cancer and neurodegenerative diseases.
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